All of this is bad. Triglycerides can accumulate in liver cells and impair their function. Triglycerides in the bloodstream can contribute to the formation of fat-filled plaque within artery walls. Free radicals (also known as reactive oxygen species) have the potential to harm cell structures, enzymes, and even genes. Uric acid has the ability to inhibit the production of nitric oxide, a substance that helps protect the artery walls from damage. Insulin resistance, a precursor to diabetes, is another effect of high fructose consumption.

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https://medium.com/@dataguy.cmi/fructose-is-a-type-of-sugar-which-mostly-occurs-naturally-especially-in-fruits-be86223eb585