Bonnibelle · Newsroom
The preparation of oncolytic virus
Many viruses have the ability to kill cancer naturally, and companies have been studying engineered viruses to target certain tumor types, such as herpes virus, pox virus, adenovirus, polio virus, etc.January 16, 2020
Introduction to effective methods for exosomes isolation
Exosomes are nano-scale vesicles secreted by cells. These microvesicles are usually about 30-150 nanometers in diameter and contain important cellular molecules such as proteins and RNA.January 15, 2020
The first medicine to prevent migraine during past decades
In 2018, an article published in Nature Reviews Drug Discovery showed that the FDA has approved 475 G protein-coupled receptor (GPCR) -related targeted drugs, accounting for 34% of all FDA-approved drugs.January 14, 2020
Methods of de novo drug design by computer-aiding (part two)
The molecular fragment approach is nicknamed the chemical number holding algorithm or the fragment joining algorithm, and was proposed by Qu et al. in 1991.January 13, 2020
Anti-cancer Breakthrough-CD47 Antibody Immunotherapy
The CD47-SIRPα axis is the first tumor phagocytosis checkpoint to be discovered.January 12, 2020
Co-immunoprecipitation: the definition, principle, pros and cos
Co-immunoprecipitation (Co-IP) is a classical method for studying protein-protein interactions based on the specific role of antigens and antibodies.January 10, 2020
What factors determine the treatment effect of MSC (Part One)
The clinical research of MSC has been carried out for many years, but various treatment results have been obtained.January 6, 2020
How much do you know about interferon family
In terms of cytokine drugs, Interferon (IFN) may be familiar to you. At present, interferon is a very popular drug.December 29, 2019
Innovative Technologies for Rapid HIV Detection in Recent Years
This article describes the development of new technologies in the field of HIV testing in recent years.December 16, 2019
Basic information about amplicon sequencing
Amplicon sequencing is a highly targeted method for analyzing genetic variations in specific genomic regions. Ultra-deep sequencing of PCR products (amplicons) can effectively identify mutations and characterize them.December 15, 2019
Advances in plant CRISPR genome editing technology (Part Three)
CRISPR / Cas9's simple and powerful multi-site editing capability is one of its significant advantages. Realizing multi-site editing requires simultaneous expression of multiple gRNA molecules.December 12, 2019
Application of Metabolomics in Food Testing
The most striking feature of metabolomics is its overall analytical ability to better reflect the impact of the environment on food composition.December 9, 2019
Introduction to Coagulation Factor Ⅷ
Recombinant mouse anti factor VIII antibody G99 is capable of binding to coagulation factor VIII C2 domain, expressed in Chinese Hamster Ovary cells (CHO).November 29, 2019
Subunit vaccine and its application
Subunit vaccine is made from special immunologically active protein fragments extracted by chemical decomposition or proteolysis from bacteria and viruses.November 27, 2019
Overview of IgG Antibodies and Anti-human IgG Antibodies
The IgG antibody is one of the types of mammalian antibodies (also known as immunoglobulins, Ig for short).November 26, 2019
Several protein modification methods (Part One)
The human proteome contains more functional polypeptides than all genes contained in the genome, in part due to simultaneous and post-translational protein modifications.November 25, 2019
Food safety: microbial contamination is a big problem
The theme of "World Health Day" on April 7th is "food safety is the shared responsibility of everyone who grows, processes, transports, stores, sells and consumes food."November 21, 2019
What can be done if cancer turns resistance to KRAS inhibitors?
Recently, KRAS and KRAS-G12C mutant inhibitors, which were previously considered to be "non-drugable" targets, have ignited a development boom.November 18, 2019
A detailed introduction to recombinant protein drugs (Part Two)
The process of obtaining recombinant protein drugs from their proteins belongs to genetic engineering pharmacy;November 14, 2019
A full list of tumor markers used for lung caner
The rapid development of society brings us high-quality life, as well as diseases, one of the most fearful is cancer.November 10, 2019
The Introduction of Bordetella (Part One)
The genus Bordetella contains eight species, of which only three have been studied in detail — Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.October 31, 2019
The history of autoimmune disease and animal models (part one)
In the present article, He will especially comment on the changes in the field that mark the transition into the 21st century, which reflect a combination of broadly based systematic research.October 30, 2019
Introduction of High-efficient Expression of Recombinant Antibody
Since the birth of hybridoma technology in 1975, monoclonal antibodies (MAbs) have been regarded as "magic bullets".October 24, 2019
Antibody Drugs and Cell Therapy for Tumor Microenvironment
According to the World Health Organization (WHO), cancer is the second leading cause of death in the world.October 23, 2019
A brief Market Analysis of Mass Spectrometer Industry
The spectrometer has outstanding technical advantages in terms of material characterization, sensitivity and speed of analysis.October 20, 2019
Study on function of plant growth regulator
Plant growth regulator is a kind of substance which has similar physiological and biological effects with plant hormones.October 17, 2019
A prediction of gene sequencing application areas and scale
The upstream of the gene sequencing industry is the supply of sequencing instruments, sequencing reagents and consumables.October 14, 2019
A Leading Service Provider in Phage Display & Antibody Library
Founded by scientists who are dedicated to the conquering of cancer, Creative Biolabs believes to build up a custom-service-centered business model that is crucial for optimizing the drug development processSeptember 27, 2019
An overview of 18 kinds of amino acids and their efficacy (part I)
It is known that there are twenty varieties of basic amino acids, among which lysine, threonine, leucine, isoleucine, valine, methionine, tryptophan and phenylalanine cannot be manufactured by the human body.September 26, 2019
Ivd antibodies provider for different studies
Creative Biolabs convinces that the establishment of a custom-service-centered business model will become the key to optimizing the drug discovery and development processSeptember 24, 2019
An overview of Lung Cancer
As one of the leading causes of cancer death in many industrialized countries, Lung Cancer (LC) claims more than 160,000 and 50,000 lives annually in the America and Japan respectively.September 22, 2019
Antioxidative Components in Plant Extracts
The antioxidant active ingredients of plant extracts mainly include alkaloids, saponins, vitamins, polyphenols, polypeptides and polysaccharides.September 21, 2019
Study on protein binding and expression
The interaction between white matter and proteins constitutes one of the main components of the cellular biochemical response network.September 20, 2019
Speeding Up Cell Variation Research with CD Genomics’ Advanced Single-Cell Sequencing Solution
Scientists from CD Genomics have developed a new platform for comprehensive single-cell sequencing—GenSeq.September 19, 2019
An Overview of Protein Identification Methods
Traditional protein identification methods, such as immunoblotting, chemical sequencing of endosomes, coigration analysis of known or unknown proteinsSeptember 16, 2019
How can we lower the cost of CAR T cell therapy?
In August of 2018, Novartis's first CART therapy was approved for marketing in the United States. While people are excited about new anti-cancer therapies, their prices have also sparked a huge controversy.August 15, 2019
Antibody Affinity Maturation Strategy
At present, the development of pharmaceutical antibodies is mainly based on hybridoma cells or in vitro antibody libraries.August 14, 2019
An overview of antibody-drug conjugates
An antibody-drug conjugate (ADC) can be defined as a prodrug. Antibodies recognize targets that expresse tumor antigens, and are coupled to a cytotoxin "warhead" by a linker to form a targeted delivery system for tumor cells.August 13, 2019
Mechanism of action of pancreatic cancer and related vaccines
With the improvement of people's living standards and changes in life and work, more and more people are suffering from cancer, such as lung cancer, skin cancer, and liver cancer.August 12, 2019
Biotechnology overview: cell engineering of glycoprotein production
In pharmaceutical companies, the production of glycoproteins is achieved in cell transient or stable gene expression systems.August 11, 2019
The isolation and culture of primary tumor cell
Compared to cell lines, primary cell culture is more able to reflect the physiological state of cells in the body.August 9, 2019
An overview of experiments with nonhuman primates
Non-human primates (NHPs) are the closest relatives of human beings. Their organizational structure and physiological functions are similar to humans.August 7, 2019
Several Main Applications of Biotin Markers
The biotin-avidin system (BAS) is a new type of biological reaction amplification system developed in the late 1970s.August 3, 2019
Clinical application of gene therapy in tumor and genetic diseases II
AIDS, also known as acquired immunodeficiency syndrome, is caused by human immunodeficiency virus (HIV) infection. After entering the human body, HIV mainly attacks CD4-positive T lymphocytes, destroying the body's immune system.August 2, 2019
Four historical development stages of gene therapy
According to historical landmark events, the development of gene therapy can be roughly divided into four stages: initial exploration, fanatic development, stumbling and advancing, and prosperity again.July 25, 2019
Gene therapy: the transgenic techniques (part two)
Adeno-associated virus is a type of single-stranded linear DNA-deficient virus with a genomic DNA of less than 5Kb, no envelope, and a bare icosahedral particle.July 21, 2019
Focus on the pharmaceutical evaluation of innovative antibody drugs
Since the industry and regulatory agencies have been accumulating innovative antibodies development and review experiences, applicants often lack sufficient reference to the production processJune 28, 2019
A list of studies: recent advances in CAR-T cell therapy (part four)
Mol Ther Oncolytics: Coarse corn particles cause negative effect on eggshell quality of semi-heavy laying hensJune 27, 2019
Technical Principle and Methods Applied in SNP Genotyping
SNP, single nucleotide polymorphism, is caused by the change of single nucleotide. Generally, only two alleles can be found in an SNP locus, because of which, it is also called the biallelic gene.June 26, 2019
Introduction to antigen and its basic properties (part two)
Incomplete antigen, also known as hapten, is an immunoreactive, non-immunogenic substance. After the hapten is combined with the protein carrier, immunogenicity is obtained.June 21, 2019