Zirconia (ZrO2) is often a ceramic material with adequate mechanical properties for manufacturing of healthcare devices. Zirconia stabilized with Y2O3 has the top properties for these applications. When a anxiety occurs on a ZrO2 surface, a crystalline modification opposes the propagation of cracks. Compression resistance of ZrO2 is about 2000 MPa. Orthopedic research led to this material getting proposed for the manufacture of hip head prostheses. Prior to this, zirconia biocompatibility had been studied in vivo; no adverse responses have been reported following the insertion of ZrO2 samples into bone or muscle. In vitro experimentation showed absence of mutations and good viability of cells cultured on this material. Zirconia cores for fixed partial dentures (FPD) on anterior and posterior teeth and on implants are now available. Clinical evaluation of abutments and periodontal tissue should be performed before their use. Zirconia opacity is very useful in adverse clinical conditions, by way of example, for masking of dischromic abutment teeth. Radiopacity can help evaluation for the duration of radiographic controls. Zirconia frameworks are realized by using computer-aided design/manufacturing (CAD/CAM) technologies. Cementation of Zr-ceramic restorations might be performed with adhesive luting. Mechanical properties of zirconium oxide FPDs have proved superior to these of other metal-free restorations. Clinical evaluations, which happen to be ongoing for 3 years, indicate a good results rate for zirconia FPDs. Zirconia implant abutments may also be used to enhance the aesthetic outcome of implant-supported rehabilitations. Newly proposed zirconia implants look to have superior biological and mechanical properties; further research are required to validate their application.