LONDON, 19 May— Erectile dysfunction (ED) affects an estimated 4.3 million men in the United Kingdom, according to NHS data. Despite its widespread prevalence, significant gaps remain in public awareness of available treatment options. A London-based private clinic, pshots.co.uk, has published a comprehensive clinical guide comparing NHS-funded erectile dysfunction treatments with regenerative options — specifically the P shot — to help men make properly informed decisions about their care.
The guide, authored under the clinical oversight of Dr Syed Nadeem Abbas (MBBS, MRCS RCS Edinburgh, MRCGP, MSc Aesthetic Plastic Surgery with Distinction — Queen Mary University London), is available at pshots.co.uk and addresses the growing patient interest in PRP-based regenerative therapy for ED alongside, or following, conventional NHS treatment.

About the Publication
The clinical guide provides a structured, evidence-based review of the full treatment landscape available to men in the United Kingdom. It covers NHS first-line and second-line options — including oral PDE5 inhibitors, alprostadil injections, vacuum erection devices, psychosexual therapy, and penile prosthesis surgery — and sets these alongside emerging evidence for the P shot treatment, also known as the Priapus shot.
The guide references NICE guideline NG242, NHS clinical protocols, and peer-reviewed literature including a 2021 systematic review in Sexual Medicine Reviews (Matz et al.) and a 2020 randomised controlled trial (Ruffo et al.) examining intracavernosal PRP injection in men with vasculogenic ED.

Key Clinical Findings Addressed in the Guide
NHS Treatments Remain the Established Standard of Care
NHS pathways provide men with access to well-evidenced, cost-effective treatments. PDE5 inhibitors — including sildenafil, tadalafil, and vardenafil — are effective in approximately 60–70% of men with mild to moderate ED, according to NICE. Alprostadil penile injection therapy achieves response rates of 70–80% and remains effective even in men with significant neurological or vascular damage.
The guide makes clear that NHS treatments remain the appropriate first point of contact for any man presenting with new-onset erectile dysfunction.
The P Shot Offers a Regenerative Mechanism Distinct from Pharmacological Options
The P shot — formally the Priapus shot — uses platelet-rich plasma (PRP) derived from the patient's own blood. Growth factors contained within the PRP, including PDGF, VEGF, and TGF-β, stimulate angiogenesis, collagen remodelling, and neural tissue repair when injected into the penile tissue.
This mechanism differs fundamentally from pharmacological agents such as alprostadil, which produce an acute erectile response. PRP therapy for men's performance issues targets longer-term tissue-level recovery rather than immediate symptomatic relief.
Clinical Evidence for the P Shot Continues to Develop
The 2021 systematic review in Sexual Medicine Reviews examined ten clinical studies. It found consistent improvements in International Index of Erectile Function (IIEF) scores following PRP injection in the majority of studies reviewed. The 2020 randomised controlled trial by Ruffo et al. reported statistically significant improvements in erectile function in men with vasculogenic ED, with no serious adverse events recorded.
The guide acknowledges the limitations of the current evidence base. Most studies involve small sample sizes, long-term follow-up data beyond twelve months is limited, and NICE has not yet issued specific guidance endorsing PRP for erectile dysfunction. The treatment is not currently available on the NHS.
Realistic Outcomes for P Shot Before and After Assessment
For men seeking to understand P shot before and after outcomes, the published evidence reports IIEF score improvements in 60–75% of treated patients. Some men report increased penile sensitivity and modest improvements in girth. Results typically become apparent within four to twelve weeks. Repeat treatment may be required at six to twelve month intervals. The guide emphasises that P-shot before and after outcomes vary by individual, underlying cause of ED, age, and cardiovascular health status.
Priapus Shot Price and Accessibility in London
The priapus shot price at private clinics in London typically ranges from £800 to £2,000 per session. The guide advises men to obtain a full itemised breakdown during consultation. It also distinguishes clearly between the P shot and other injectable procedures — such as hyaluronic acid filler augmentation — which have different mechanisms and risk profiles. Men researching male enlargement injections cost UK are encouraged to clarify the treatment type and evidence base before proceeding.
Choosing a Provider for P Shot London Treatment
The guide advises men seeking P shot London services to verify that the treating practitioner holds a current GMC registration, that the clinic uses CE-marked or medically approved PRP preparation equipment, and that written informed consent and post-treatment follow-up are standard practice. Clinics offering Priapus shot London services are concentrated in central London, particularly in the Harley Street and Marylebone area.


Clinical Commentary
Dr Syed Nadeem Abbas, the lead practitioner at pshots.co.uk, states:
"Erectile dysfunction has a significant impact on quality of life, and men deserve access to clear, balanced information about every available option. NHS treatments are well-evidenced and remain the first step for most men. The P shot represents an emerging regenerative approach with a growing evidence base. Our role is to provide men with an accurate, honest overview so they can make decisions that are right for their specific clinical situation — not to position any treatment as a universal solution."

About pshots.co.uk
pshots.co.uk is a private medical clinic based on Harley Street, Marylebone, London. The clinic is led by Dr Syed Nadeem Abbas, who holds qualifications from Cambridge, Oxford, and the Royal London Hospital, and an MSc in Aesthetic Plastic Surgery with Distinction from Queen Mary University London. The clinic provides non-surgical treatment for erectile dysfunction in London, including advanced PRP solution for erectile dysfunction, within a fully regulated clinical environment.
The clinic focuses on men's intimate health treatment in London and offers consultations for men seeking PRP-based regenerative therapy for ED, natural ED treatment using PRP therapy, and other evidence-informed regenerative approaches to male health.